Top 100 genes with highest variance across all samples separates mutant from A-D-M WT PanNETs and showed relatively high expression of “liver-specific” genes (APOH, ALDH1A1, FGB, APOC3 etc.)as well as complement and coagulation pathway genes (SERPINA1, FGA, F10, CP, MT3 etc.)in A-D-M mutant PanNETs (Fig. 2d; Supplementary Figure 3), both in primary (collected in absence of liver tissue) and metastatic tumors. This evidence concerns the gene APOH and metastatic neoplasm.