Increased binding of aSYN and pTau to vesicular lipid membranes in the aging brain and in PD could result in a reduction of aSYN and Tau in other fluid compartments, and consistent with such reasoning, decreases in aSYN and pTau have consistently been reported in the CSF of patients with PD, and during aging52–54. This evidence concerns the gene MAPT and Parkinson disease.