NFKB1 and myelodysplastic syndrome: NF-κB activation in OP9 cells resulted in overexpression of NFKBIA (Fig. 2c) and canonical NF-κB downstream negative regulators of hematopoiesis, including Il6, Cxcl2 (murine homolog of IL8), Ccl3, Inhba, Fth1, Ltf, Ccl5, and Cxcl4 (Fig. 2b), recapitulating the findings in LR-MDS patients.