HK2 and hepatocellular carcinoma: Genistein, a natural isoflavone, enhanced the antitumor effects of sorafenib in sorafenib-resistant HCC cells and an HCC xenograft mouse model by downregulating HIF-1α, therefore inactivating GLUT-1 and HK2 to suppress glycolysis and sensitize aerobic glycolytic HCC cells to the mitochondrial apoptosis47.