Likewise, transfection of HIF-2α siRNA decreased the expression of TGF-α, VEGF, and cyclin D1, and repressed the activation of EGFR, inhibiting the proliferation and promoting the apoptosis of HCC cells in vitro; HIF-2α siRNA also synergized with sorafenib to suppress the growth of HCC tumors in vivo26. Here, CCND1 is linked to hepatocellular carcinoma.