Three isoforms of the HIF-α subunit (HIF-1α, HIF-2α, and HIF-3α) have been described, and the overexpression of HIF-1α and HIF-2α has been detected in different liver diseases, including nonalcoholic fatty liver disease, alcoholic liver disease, radiation-induced liver injury, and HCC23. The gene discussed is EPAS1; the disease is metabolic dysfunction-associated steatotic liver disease.