All five mice succumbed, becoming moribund at 90–119 days of DOX treatment (median = 118 days; Fig. 5a; p = 0.002; Fig. 5a); flow and morphological analysis revealed AML in all mice analyzed, with the bone marrow replete with blast forms (Fig. 5b), which, by immunophenotyping by flow cytometry, were positive for Mac1 (CD11b) (Fig. 5c). Here, ITGAM is linked to acute myeloid leukemia.