Adding CQ further enhanced the anti-cancer efficacy for the TNP-1-mediated, but not the TNP-2-mediated, PTT, as the tumor weight of the TNP-1 + NIR + CQ group decreased by 92% compared to the PBS + NIR group, while the corresponding number was only 59% for the TNP-2 + NIR + CQ group, revealing a statistically significant difference between the two chemo-PTT groups (p < 0.001, Student’s t-test). Here, TNP2 is linked to neoplasm.