Similar to CQ, 3-MA further enhanced the anti-cancer efficacy for TNP-1- but not TNP-2-mediated PTT, as the tumor weight of the TNP-1 + NIR + 3-MA group decreased by 91% compared to the PBS + NIR group, while the corresponding number was only 67% for the TNP-2 + NIR + 3-MA group. This evidence concerns the gene TNP2 and cancer.