Risk scores for clinical autoimmune thyroid disease, lipid traits, and type 2 diabetes were found to be significantly associated with BD phenotype (broad extended, broad and narrow) (Fig. 2a), whereas only thyroid hormone, LDL, and triglyceride risk scores were nominally associated with depression phenotype (for full results, see Supplemental table 8). This evidence concerns the gene TG and type 2 diabetes mellitus.