The decrease of eTreg cells and PD-1 expression by CD8+ T cells in TILs in some PR patients may be a reflection of reduced tumor burdens, whereas this tendency was also observed at PD state, suggesting that RAM-containing therapies can reduce eTreg cells and PD-1 expression by CD8+ T cells in TILs independently of clinical responses. Here, CD8A is linked to neoplasm.