It should be noted that the identified miRNAs have among their predicted targets several AD relevant proteins involved in Abeta generation (e.g. Aph1a, Aph1b) or TAU kinases (e.g. Gsk3β, Cdk5, Camk2a), phosphatases (e.g. Pten, Ppp2ca) and protein TAU itself (see Additional file 1: Table S4). The gene discussed is CDK5; the disease is Alzheimer disease.