It should be noted that the identified miRNAs have among their predicted targets several AD relevant proteins involved in Abeta generation (e.g. Aph1a, Aph1b) or TAU kinases (e.g. Gsk3β, Cdk5, Camk2a), phosphatases (e.g. Pten, Ppp2ca) and protein TAU itself (see Additional file 1: Table S4). This evidence concerns the gene APH1B and Alzheimer disease.