SERPING1 and hereditary angioedema: There are now four US Food and Drug Administration (FDA)-approved on demand treatments for HAE attacks: intravenous (IV) plasma-derived C1-INH [C1-INH(IV) Berinert®, CSL Behring, Marburg, Germany]; subcutaneous (SC) icatibant (Firazyr®, Shire, Lexington, MA); SC ecallantide (Kalbitor®, Shire), and IV recombinant human C1-INH (Ruconest®, Pharming Healthcare, Inc., Berkeley Heights, NJ).