GFAP and AIDS: Neurogenesis is important to study in the context of HAND, because HIV-1 virions have been found in the hippocampal formation of pediatric AIDS patients [18], and impaired neurogenesis has been observed in both HIV-1-infected patients and SIV-infected macaques [19, 20], as well as glial fibrillary acidic protein (GFAP)-driven gp120 transgenic mice [21–25] and GFAP-Tat transgenic mice [26, 27].