Their results showed that 3WHP could reduce the inflammation in the ankle of rats with acute gouty arthritis and this was related to the inhibition of TNF-α, IL-6, and IL-8 levels in the ankle synovial tissues of gout rats which were associated with the downregulation of NF-ΚB P65 protein expression by 3WHP. The gene discussed is CXCL8; the disease is gout.