In 4 patients the planned HREZ or HRE regimen was changed to X-based regimen due to drug eruption (n = 1), drug eruption and liver dysfunction (n = 1), thrombocytopenia (n = 1), and preventing the drug interaction between Paclitaxel and RFP via CYP3A4 and CYP2C8 (n = 1). Here, CYP3A4 is linked to Decreased liver function.