It should be noted, however, that arterial thrombosis in cancer can occur in the absence of an atherosclerotic plaque such as that observed in cardiovascular patients, where systemic hypercoagulation is induced by several secreted factors from cancer cells, such as thrombin and vascular endothelial growth factor (VEGF), thereby promoting platelet activation and coagulation [20]. The gene discussed is VEGFA; the disease is deep vein thrombosis.