SLC7A5 and familial pancreatic carcinoma: For example, l-type amino acid transporter 1 (LAT-1), a representative amino acid transporter, is overexpressed in various types of cancer cells [14], and interestingly, LAT-1 expression has been consistently reported to be elevated in patients with pancreatic cancer and in transplanted Colo357 cells (a pancreatic cancer cell line) [15,16].