In diabetic nephropathy, elevated expression of renal NADPH oxidase and endothelial nitric oxide synthase (eNOS) resulted in oxidative stress with elevated lipid peroxidation which was inhibited following treatment with an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB) agent in rat models [13]. The gene discussed is ACE; the disease is diabetic kidney disease.