A great number of mechanisms contributing to this phenomenon consist of loss of dietary intake due to diabetic gastroparesis and uremia, diminished renal and hepatic clearance of insulin with prolongation of insulin half-life, impaired renal gluconeogenesis, protein-energy wasting, disrupted counter-regulation of hypoglycemia, imposed dietary restriction, and hypoglycemia effects of dialysis [22,23]. Here, INS is linked to Hypoglycemia.