PTGS1 and ovarian cancer: Accordingly, the expression of COX-1 is higher in ovarian cancer patients with low CD8+ (cytotoxic T cells) and high CD1a+ (dendritic cells) cell density than in those with high CD8+ cell density [113], and COX-1 overexpression is the characterizing element in a cluster of ovarian cancer patients in which the poor prognosis is associated with an immunosuppressive status [114].