COX-1, but not COX-2, is expressed and enzymatically active also in primary blasts from patients affected by acute promyelocytic leukemia (APL), a distinct AML subtype characterized by the t(15;17) translocation involving the PML gene on chromosome 15 and the retinoic acid receptor-alpha (RAR-alpha) gene on chromosome 17. This evidence concerns the gene PTGS1 and acute myeloid leukemia.