Furthermore, analysis of the expression levels of COX-1, COX-2, and mPGES (the downstream prostaglandin E synthase) in COX-1−/− and COX-2−/− ApcΔ716 double-knockout mice revealed that COX-1 was required from the early stage of intestinal polyp development, and that additional expression of COX-2 together with mPGES was necessary for subsequent accelerated growth of polyps [72]. Here, PTGS1 is linked to intestinal polyp.