A significant correlation between levels of mRNA for COX-1, COX-2, TGF-beta1 and PGES, and those for proangiogenic factors VEGF-A and VEGF-C were also found in primary adenocarcinomas of the small intestine, thus suggesting a role for these factors in the propagation this rare neoplasia [70]. This evidence concerns the gene PTGS2 and neoplasm.