PTGS2 and neoplasm: The role of cyclooxygenases (in particular COX-2) and prostaglandin products (in particular PGE2) in cancer-related inflammation has been extensively investigated in many neoplastic diseases, including esophageal [24], gastrointestinal [25,26] and pancreatic [27] cancers, breast [28] and cervical [29] cancers, renal [30], prostate [31], and bladder [32] cancers, skin [33,34] and head and neck [35] cancers, hematological tumors [36], and mesothelioma [37].