IL2 and autoimmune hepatitis: In our mouse model of immune-mediated hepatitis that reflects several aspects of T cell activation including cytokine response observed in autoimmune hepatitis [Concanavalin A (ConA) hepatitis, [217,218,219]], we have demonstrated that induction of intrahepatic regulatory T cells depends on IL-2 production by CEACAM1+CD4+ T cells, as IL-2 production was significantly reduced in CEACAM1−CD4+ T cells [195].