L-SACC1 mice with transgenic liver-specific overexpression of the phosphorylation-deficient dominant-negative Ser503Ala mutant under the control of apolipoprotein A1 promoter [101] develop impaired insulin clearance, which causes chronic hyperinsulinemia and secondary systemic insulin resistance, glucose intolerance and hepatic steatosis [101]. This evidence concerns the gene INS and hyperinsulinism.