INS and hyperinsulinism: Global null deletion of the Ceacam1 gene and liver-specific inactivation of CEACAM1 impairs insulin extraction to cause hyperinsulinemia, followed by insulin resistance and secondary increase in hepatic lipid production and redistribution to the white adipose tissue to yield visceral adiposity and lipolysis [31,101,117,124,125,126,127,128,129] (Figure 4).