Other studies have reported that the development of DN is associated with infiltration of inflammatory cells, increase in plasma levels of C-reactive protein (CRP) and proinflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), interleukins (IL-1, IL-6, and IL-18) and tumor necrosis factor-α (TNF-α) [4]. This evidence concerns the gene IL1B and liver dysplastic nodule.