The elevated ALT threshold value of males and females was ≥30 U/L and ≥ 25U/L, respectively.[31] A study conducted in the north of China showed that the ALT in the normal range or close to normal range was associated with metabolic disorders; the ALT boundary value for determining metabolic disorder was 21–25 U/L for males and 12 to 22 U/L for females. The gene discussed is GPT; the disease is metabolic disease.