HP and gastrointestinal disease: Hp is a gram-negative bacterium and the etiologic agent of some extra gastrointestinal diseases, and the condition of the nasopharynx is more favorable for the growth of this bacterium, especially in adenoid hypertrophy.[14,15] We included 3 articles in our meta-analysis for the detection of Hp in the adenoid specimen and in Hp subgroup analysis, with a corresponding value of 2.39 (95% CI: 0.39–14.55, P < .05) under the random-effects model.