Our immunohistochemistry results showed that CD11b-positive cells are the main cellular correlate to TSPO uptake beyond reactive astrocytes, consistent with results of previous studies, using 18F-DPA-714 ligand in a weight-drop closed head injury mouse model (Israel et al., 2016), fluid percussion injury model in rats (Cao et al., 2012), and focal cerebral ischemia injury rat model (Martín et al., 2010). This evidence concerns the gene ITGAM and brain ischemia.