CLCA4 and cirrhosis of liver: In addition, low CLCA4 expression (P < 0.001), high AFP level (P = 0.004), high GGT level (P = 0.010), liver cirrhosis (P = 0.019), larger tumor (P < 0.001), satellite nodule (P = 0.002) and vascular invasion (P < 0.001) were unfavourable prognostic factors for TTR of HCC patients (Table 2).