Kaplan-Meier analysis revealed that the patients with low CLCA4 expression (P < 0.001), high AFP level (P < 0.001), high GGT level (P = 0.017), liver cirrhosis (P = 0.007), larger tumor (P < 0.001) and vascular invasion (P < 0.001) had shorter OS time. The gene discussed is CLCA4; the disease is cirrhosis of liver.