VILIP-1 primarily had negative associations with ventricle size in Aβ- and Aβ + individuals, which was seen in longitudinal analyses of cognition (in Aβ+), hippocampal atrophy (in Aβ- and Aβ+), and expansion of ventricles (in Aβ- and Aβ+). This evidence concerns the gene VSNL1 and hippocampal atrophy.