In summary, our results show that VILIP-1 or YKL-40 is not better than P-tau in the diagnostic accuracy for AD and MCI, and combinations of p-tau, VILIP-1, and YKL-40 do not increase the diagnostic accuracy for CN versus AD and for sMCI versus pMCI, while p-tau and VILIP-1 have correlations to Aβ pathology and the clinical stages of AD, and VILIP-1 and YKL-40 may respond to neurodegeneration in AD. The gene discussed is CHI3L1; the disease is Alzheimer disease.