Between CN Aβ- and all other combinations of diagnosis and Aβ pathology, compared to CN Aβ-, p-tau was increased in all Aβ + groups (CN Aβ+, sMCI Aβ+, pMCI Aβ+, and AD Aβ+) (Table 5 and Fig. 3a), and VILIP-1 was increased in pMCI Aβ + and AD Aβ + (Table 5 and Fig. 3b), while YKL-40 was increased in CN Aβ + and AD Aβ + (Table 5 and Fig. 3c). The gene discussed is MAPT; the disease is Alzheimer disease.