In addition to the central nervous system, highly glycosylated IgSF-CAM members also play critical roles in other systems affected in CDG patients, such as the developing eyes (Morava et al., 2009) and immune system with ICAM1 (Blank et al., 2006; He et al., 2014), or in other diseases like cancer, where L1CAM plays a critical role in tumor metastasis (Kiefel et al., 2012) (Agrawal et al., 2017). Here, ICAM1 is linked to neoplasm.