PPARGC1A and hepatocellular carcinoma: SESN2 plays a crucial role in cell survival and cellular metabolic rewiring.20, 54 Bensahra et al21 found that SESN2 protected cells from energetic stress‐induced death and Kumar et al55 reported that SESN2 raised the expression of peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) in HepG2 cells and facilitated survival of HCC cells after chemotherapeutic agents treatment.