STAT3 and neoplasm: We observed that there was significant upregulation of phosphorylated STAT3 (pSTAT3) in tumor‐driven like macrophages than hTERT‐HPNE‐CM‐treated or parent THP‐1 monocytes, and we also found that hTERT‐HPNE‐CM upregulated pSTAT3 level in THP‐1 monocytes slightly (Figure 4A).