IL10 and neoplasm: It has been also proven that TAMs‐derived IL‐8 plays a vital role in tumor progression in other malignancies.18, 29 Recently, a research using different TAMs model indicated TAMs‐derived IL‐10 enhanced the metastasis of PDAC cells.10 In that study, the authors chose mouse macrophages RAW 264.7 as the origin of TAMs following by treated with IL‐4, which are quite different from human monocyte cell lines THP‐1 used in this study.