NFKB1 and cancer: To our best knowledge, NF‐κB and STAT3 pathways play important roles in control of communication between cancer cells and inflammatory cells,20 and furthermore, both of them are involved in regulating the secretion of IL‐8.21, 22 Therefore, we detected whether the two pathways were activated in tumor‐driven like macrophages via Western blotting after exposing to corresponding CM for 48 hours.