CXCL8 and neoplasm: Multiple cell types in the tumor microenvironment, such as neutrophils, macrophages, or fibroblasts, can secrete IL‐8 in response to kinds of stress factors.37 Conversely, high‐level of IL‐8 expression can also lead to intensive recruitment of neutrophils and TAMs.38 Recently, Fang et al39 have showed that higher levels of IL‐8‐positive Tumor‐infiltrating inflammatory cells (TIICs) but not tumor cells in PDAC patients correlated with worse prognosis, and as we know, TAMs is one of the most important TIICs subtype.