In a recent report, human NSUN1 was found to interact with the chromatin regulator bromodomain containing protein 4 (BRD4) and actively elongating RNA polymerase II, and this association was increased in 5‐azacytidine‐resistant versus sensitive leukemia cell lines and in patient derived samples (Cheng et al., 2018) suggesting a role for NSUN1 in transcriptional regulation. The gene discussed is NOP2; the disease is leukemia.