Third, we did not have other measurements of obesity like visceral fat and waist circumference, change in BMI during the 4-month treatment period, or concentrations of other pro-inflammatory mediators, which may provide valuable information on a possible role of CHI3L1 and CHIT1 in the progression of OSA. This evidence concerns the gene CHI3L1 and obesity due to melanocortin 4 receptor deficiency.