ACTH-dependent Cushing’s syndrome is caused by excess secretion of ACTH from the pituitary, which is named Cushing’s disease (CD), or by ectopic secretion of ACTH from neuroendocrine tumors, which is named ectopic ACTH syndrome (EAS), or rarely by ectopic secretion of corticotropin-releasing hormone (CRH) [1]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.