There are similar clinical and physiopathological phenomena between allergic and nonallergic asthma: both can be triggered by exercise, inhaled irritants, or upper airway tract infection; both are associated with rhinitis and both can have higher total serum IgE, airways IgE, airways Th2 cells and Th2, and eosinophilic chemokines and cytokines. Here, IGHE is linked to asthma.