In fact, in our previous study, it was confirmed that siRNA-mediated knockdown of M-LPH had no influence on the mtDNA content of HK-2 cells [20], normal human renal proximal tubule epithelial cells (RPTEC), and human breast cancer cells (MDA-MB-453) (R. Iida, M. Ueki, and T. Yasuda, unpublished data). Here, MLPH is linked to breast carcinoma.