In AD, acetylcholinesterase (AChE) inhibitors,leading to inhibition of acetylcholine (ACh), breakdown andmake a way for disease, several strategies to elaborate the diseaseon the characteristics of symptoms, although the one of that hasbeen most successful till is "cholinergic hypothesis" strategies.(https://jnnp.bmj.com/content/jnnp/66/2/137) [4], the currentFDA approved mostly drugs are follows the cholinergichypothesis, the ACh deficit is; they try to enhance the ACh levelin the diseased brain. The gene discussed is ACHE; the disease is Alzheimer disease.