The GG genotype remained a significant covariate for 90-day mortality risk (hazard ratio: 0.624; 95% CI: 0.399-0,975; p = 0.03858) [Table 2], indicating that despite potential confounders, the CTLA-4 rs231775 GG genotype is an independent prognostic variable for survival of patients with sepsis. This evidence concerns the gene CTLA4 and Sepsis.