MT-RNR2 and age-related macular degeneration: However, AMD cybrids treated with SHLP2 showed substantially augmented OXPHOS complex protein subunit levels as represented by an increase in the levels of NADH-coenzyme Q oxidoreductase (Complex I subunit) by 24%, Succinate-coenzyme Q oxidoreductase (Complex II subunit) by 59%, Coenzyme Q-cytochrome c oxidoreductase (Complex III subunit) by 37%, Cytochrome c oxidase (Complex IV subunit) by 46%, and ATP synthase (Complex V subunit) by 38%.