ZBTB38 and leukemia: In three additional human cancer types (U2OS, HepG2, and HCT116) and two leukemia cell types (THP-1 and MOLM-14) we also observed that exposure to 5-azacytidine causes the down-regulation of ZBTB38 protein abundance without altering the mRNA level (Fig. 1f, g and Supplementary Fig. S1A, B).