ZBTB38 expression was decreased in AML with myelodysplasia-related changes (AML-MRC) (0.52 [6.54-0.04]) and in de novo AML (0.77 [5.23–0.01]), compared to healthy donors (1.98 [31.47–1.00]), both P < 0.001 (Fig. 6a). The gene discussed is ZBTB38; the disease is acute myeloid leukemia.