Moreover, the expression of CRYAB either at the level of mRNA (from public datasets and Basurto cohort) and protein (from Basurto cohort) was consistently downregulated through the progression of the disease (Fig. 3c, d and Supplementary Figure 3B–D), supporting the association of MITF and CRYAB expression in PCa. Here, CRYAB is linked to posterior cortical atrophy.