FLT1 and psychotic disorder: Our findings are further supported by human studies, which have demonstrated that the effects of psychotic symptoms are mixed34, whereas VEGR1/Flt-1 and VEGFR2/KDR dysregulation were associated with worse psychotic symptoms in a prospective familial high risk for psychosis study35,36, a post mortem SZ study10, and in case reports of systemic VEGFR1/Flt-1 administration19,20,37.