We then compared the expression of the 10 candidate mRNAs in CD4+ T cells from 15 T-ALL and controls, finding that three mRNA including INSR, IL-6R, and MET showed significantly differential expression with the p < 0.05 (Supplementary Figure 1a and b), with the insulin receptor precursor (INSR) being most significant (p = 0.021) (Fig. 2c, left). Here, CD4 is linked to acute lymphoblastic leukemia.