By analyzing the immune status of tumor-infiltrating lymphocytes (TILs), tumor tissues, and PBMCs at various time points, Chew et al. [32] found that Tim-3+CD8+ T cells were more abundant in PBMCs of sustained responders (SRs) both before and after Y90-RE than those in non-responders. This evidence concerns the gene HAVCR2 and neoplasm.