SPRR2A and tuberculosis: Moreover, comparison between Lp ACERL and Lp ACERL/LcIL-12 of the oral group demonstrated that the positive effect of the LcIL-12 adjuvant is beneficial in improving the Th1 bias response as indicated from the immune response outcome from the cytokine profiling of spleen, lung and GIT that is important for developing protective memory against tuberculosis.