For example, MAGEC2 form complex with TRIM28 to promote TRIM28-dependent ubiquitination and degradation of tumor suppressor p53 in a proteasome-dependent manner in tumor cells [16]; MAGEA3/6 bind with TRIM28 to act as a cancer specific ubiquitin ligase and degrade AMPK tumor suppressor [45]. This evidence concerns the gene MAGEA3 and cancer.