GPX4 and neuroblastoma: We can suppose that Gpx1 isoform would be preferentially synthetized in (PhSe)2-treated HT22 cells, suggesting an interplay between the different isoforms and also suggest that (PhSe)2 regulates Gpx1-specific transcriptional machinery in HT22 cells that does not involve Gpx4. Contrary to our results, (PhSe)2 did not increase the GPx activity and protein expression in neuroblastoma cells [61], indicating that these cells would present a different physiological response than those found in HT22 cells.