Thus, serum M2BPGi levels as well as FIB4 index may reflect the extents of hepatitis activity as well as liver fibrosis in patients with HCV, and the extent of liver fibrosis was estimated from FIB4 index and serum M2BPGi levels at 4 weeks of the therapy, when serum AST and ALT levels decreased along with serum HCV-RNA disappearance in almost all patients during DCV plus ASV therapy. The gene discussed is GPT; the disease is Hepatic fibrosis.