GDF15 and obesity due to melanocortin 4 receptor deficiency: For that reason, the following genes which are located in a highly associated region for both BFT and CRCL (SSC7: 24–26 Mb) were suggested: BMP5 (7:25,344,729–25,469,988) part of the transforming growth factor-beta (TGF-beta) signaling pathway, HMGCLL1 (7:25,596,716–25,783,612, ketone body biosynthetic process GO: 0046951), GFRAL (7:25,751,185–25,808,637), a receptor required for GDF15 (Growth differentiation factor 15) mediated reductions in food intake and body weight in mice with obesity [43] and HCRTR2 (7:25,830,273–25,930,645, feeding behavior GO: 0007631).