Some of these identified genes have been previously shown to be deregulated in subsets of particular B-cell lymphomas, including HLX in HL, MSX1 in MCL, NKX2-1 in DLBCL, and NKX2-3 in SMZL, MALT lymphoma and DLBCL [22–25]. Here, NKX2-3 is linked to splenic marginal zone lymphoma.