Thus, while chromosomal rearrangements frequently mediate oncogenic activation of NKL homeobox genes in T-ALL [16,19], this type of activation seems to be less common in B-cell malignancies–an exception being SMZL where aberrant activation of NKX2-3 occurs by a chromosomal translocation, t(10;14)(q24;q32), which juxtaposes this NKL homeobox gene with the IGH locus [25]. This evidence concerns the gene NKX2-3 and acute lymphoblastic leukemia.