To assess the predictive potential of CD3+ or CD8+ cell densities in different tumour regions (CT and IM), the patients were divided into two groups using the minimum P-value cut-off values for CD3+ or CD8+ densities in each tumour region (290, 490, 70, and 116 cells per mm2 for CD3IM, CD3CT, CD8IM and CD8CT, respectively). This evidence concerns the gene CD8A and neoplasm.