The region between these two domains has been shown to contain protein-protein interaction motifs/domains including HIC1 (hypermethylated in cancer 1) binding domain (aa 1355–1451) and GR (glucocorticoid receptor) binding domains (aa 1635–2285), which partially overlaps with BAF250_C (aa 1974–2231) [8]. Here, NR3C1 is linked to cancer.