SMAD3 and cardiovascular disorder: IPA identified a high degree of enrichment for SMAD3 knockdown DE genes among those associated with “cardiovascular disease” (p = 1.62e-4–8.37e-9) (Table 1, S1 Table), including those associated with vascular developmental syndromes such as “abnormal morphology of vasculature,” “abnormal morphology of blood vessels”, “abnormal morphology of artery,” as well as those associated with atherosclerotic vascular disease, “occlusion of blood vessel”, and “atherosclerosis”.