In the highly relevant Physiological System Development and Function analysis in IPA, the top three terms identified for the SMAD3 knockdown DE genes were identical to those identified in the similar analysis conducted with the CAD GWAS associated genes identified in a recent meta-analysis [7], “cardiovascular system development and function, “organismal development” and “organismal survival.” (S2 Table). Here, SMAD3 is linked to coronary artery disorder.