These include syndromic diseases associated with aortic aneurysms, including Marfan’s and Loeys Dietz Syndromes (LDS), due to mutations in TGFβ signaling genes FBN1, TGFBR1, TGFBR2, TGFB2, and TGFB3 [64, 65]. Here, TGFB3 is linked to Loeys-Dietz syndrome.